Dr. Daniel’s Zipa-Liv.

Dr. Daniel’s Zipa-Liv contains the best available, clinically proven plants which will help in protecting and repairing and regenerating damaged liver. The plants used in Zipa-Liv, their active principles and their clinically proven activities are summarized below.

  1. Bhumi Amlaki  (Phyllanthus fraternus Webster). This plant is used mainly to treat all kinds of jaundice as a single remedy and as a choleretic and liver protectant. It contains lignans, phyllanthin and hypophyllanthin and phyllanthusin D. It increases antioxidants and reduces lipid peroxidation of hepatic cellular and intracellular membranes and protects liver damage due to free radicals and hepatitis-C. It also is found to suppress the trasnscription of hepatitis B virus mRNA and inhibits endogeneous hepatitis B viral polymerase and binds to the surface antigen of this virus. It plays a protective role against liver cirrhosis induced by thioacetamide as well as CCl4 or alcohol consumption. Phyllanthus fraternus  exhibits hypolipidaemic and dissolution of kidney and urinary stones.
  2. Bhringaraj (Eclipta alba Hassk.) Bhringaraj contains coumestan derivatives like wedelolactone and   demethylwedelolactone and thiophenes. The drug is hepatoprotective (antihepatotoxic). It is also antimyotoxic and antihaemorrhagic in nature. It has been traditionally used in Ayurvedic medicines for ages, mainly for treatment of Liver cirrhosis caused by alcohol, CCl4 or other toxins. It also protects liver from cirrhosis, jaundice, liver enlargement, and problems of gall bladder and spleen.
  3. Kalmegh  ( Andrographis paniculata Wall.) It contains diterpenoids such as andrographolide, neoandrographolide, wogonin etc. Andrographolide is found to produce a choleretic effect (stimulating bile production) more potent than silymarin. Kalmegh exhibits liver protective effects by enhancing activity of antioxidant enzymes and  reverses the effects hepatotoxins like BHC, CCl4 or other toxins.
  4. Katuka    (Picrorrhiza kurroa  Linn.). Katuka contains  iridoid glycosides picroside I, kutkoside etc  and cucurbitacin glycosides  and promotes appetite and useful in biliousness, bilious fevers, and jaundice. It is also found to be effective against CCl4 and alcohol induced chronic hepatotoxicity and protects against thioacetamide induced hepatic damage and galactosamine induced hepatitis.
  5. Sunthi   ( Zingiber officinale Ros.).  Ginger is especially useful in preventing and treating liver fibrosis by its ability to downregulate increase of free radicals, improve liver and cholestatic biomarkers, ameliorate hepatic marker enzymes, reduce collagen deposition, fibrosis severity and normalize the hepatic cells architecture.  Ethanol extract had higher potency in inhibiting collagen deposition and fibrosis severity than silymarin. Treatment with ginger was found to ameliorate fructose-induced fatty liver and hypertriglyceridemia.
  6. Mari   (Piper nigrum Linn.) Ethanol extract containing piperine alkaloids  is found to reverse the damages such as increase in levels of triglycerides, aminotranferases , alkaline phosphatase, bilirubin and decrease in  antioxidant (SOD, CAT, and GSH) levels, induced by ethanol and CCl4. It also provided significant protection to liver and kidney from the oxidative stress of MSG (monosodium glutarate- a toxin) as well as tert-butyl hydroperoxide. Supplementation with black pepper or its alkaloids can reduce high-fat diet induced oxidative stress to the cells.

Available in bottles containing 30 capsules.
Dose: One capsule a day, preferably after dinner.

Liver problems
The liver is a vital organ present in vertebrates and some other animals. It has a wide range of functions, including detoxification, protein synthesis, and production of biochemicals necessary for digestion. Problems and diseases of liver in man are due to modern life style, junk food, pesticides and microbes especially viruses. The most common problems are cirrhosis, fatty liver, jaundice, hepatitis, viral hepatitis and cancer.

Cirrhosis is a chronic condition wherein liver tissue is replaced of by fibrosis, scar tissue and regenerative nodules resulting in loss of liver function. Cirrhosis is most commonly caused by alcoholism, hepatitis B and hepatitis C, and fatty liver disease. The most common complication of cirrhosis is the fluid retention in the abdominal cavity (Ascites), hepatic encephalopathy (confusion and coma) and bleeding from esophageal varices. Cirrhosis is generally irreversible, and treatment usually focuses on preventing progression and complications. In advanced stages of cirrhosis, the only option is a liver transplant.

Fatty liver, is the accumulation of large vacuoles of triglyceride/fat accumulate in liver cells.This is seen in people with excessive alcohol intake and those who are obese. Accumulation of fat may also be accompanied by a progressive inflammation of the liver (hepatitis). Fatty liver (FL) is also caused by diabetes,hypertension, obesity and dyslipidemia, This condition is reversible.

Jaundice is characterized by a yellowish pigmentation of the skin, eyes and other mucous membranes by the increased levels of bilirubin in blood. Jaundice is often seen in liver diseases such as hepatitis or liver cancer. Complications of jaundice include fatal infections on bile duct, internal bleeding, poor blood clotting, and renal and liver failure

Hepatitis is the inflammation of the liver and characterized by the presence of inflammatory cells in the tissue of the organ. This can progress to fibrosis (scarring) and cirrhosis. Hepatitis leads to jaundice, poor appetite and malaise. Hepatitis is acute when it lasts less than six months and chronic when it persists longer. A group of viruses known as the hepatitis viruses cause most cases of hepatitis worldwide, but hepatitis can also be caused by toxic substances (notably alcohol, certain medications, some industrial organic solvents and plants), other infections and autoimmune diseases.

Viral hepatitis is liver inflammation due to a viral infection. It may be present in acute or chronic forms. The most common causes of viral hepatitis are the five unrelated hepatotropic viruses Hepatitis A, Hepatitis B, Hepatitis C,Hepatitis D, and Hepatitis E. In addition to the nominal hepatitis viruses, other viruses that can also cause liver inflammation include Herpes simplex, Cytomegalovirus, Epstein-Barr virus, or Yellow fever. Symptoms of liver disease include nausea, vomiting, right upper quadrant abdominal pain and jaundice associated with fatigue. Weakness and weight loss may also occur.